Polyendocrinopathy

Clinical information

Autoimmune polyendocrinopathies are characterised by the immunological destruction of endocrine tissues. They are characterised by the association of at least two endocrine diseases and the presence of one or more autoantibodies against endocrine organs as well as parietal cells of the stomach and striated muscle.

Diagnostics

The indirect immunofluorescence test (IIFT) on frozen sections of the organs adrenal cortex, ovary, placenta and testis is the main detection method for autoantibodies against steroid hormone-producing cells. The additional use of tissue sections of thyroid and parathyroid gland, pancreas and striated muscle enables parallel detection of numerous associated autoantibodies.

Selected Products

Method
Parameter
Substrate
Species
IIFT
thyroid gland
(MAb + TAb)
thyroid gland
monkey
IIFT
thyroid gland (MAb + TAb)
mitochondria (AMA)
thyroid gland
kidney
(2 BIOCHIPs per field)
monkey
rat
IIFT
Polyendocrinopathy Mosaic
thyroid gland (MAb + TAb)
pancreas islets
adrenal cortex
ovarian antigens
Leydig cells
parietal cells (PCA)
6 BIOCHIPs per field:
thyroid gland
pancreas
adrenal gland
ovary
testis
stomach

monkey
monkey
monkey
monkey
monkey
monkey
IIFT
EUROPLUS
thyroid gland (MAb + TAb)
thyroglobulin (TG)
2 BIOCHIPs per field:
thyroid gland
TG BIOCHIPs

monkey
human
IIFT
antibodies against thyroid microsomes
(MAb control)
ELISA
thyroid peroxidase
(TPO)
antigen-coated
microplate wells
RIA
thyroid peroxidase (TPO)
coated tubes (CT)
antigen-coated
tubes
native thyroid
peroxidase, human
RIA
thyroid peroxidase (TPO)
precipitation
labelled antigen
native thyroid
peroxidase, human
RIA
thyroid peroxidase (TPO)
magnetic separation
labelled antigen
native thyroid
peroxidase, human
IIFT
antibodies against thyroglobulin
(TAb control)
ELISA
thyroglobulin
(TG)
antigen-coated
microplate wells
RIA
thyroglobulin (TG)
coated tubes (CT); IRMA
antibody-coated
tubes
native
thyroglobulin
RIA
thyroglobulin (TG)
coated tubes (CT)
antigen-coated
tubes
native thyroglobulin,
human
RIA
thyroglobulin (TG)
magnetic separation
labelled antigen
native thyroglobulin,
human
ELISA
TSH receptor
(thyrotropin receptor)
antigen-coated
microplate wells
ELISA
TSH receptor
(thyrotropin receptor)
Fast ELISA
antigen-coated
microplate wells
RIA
TSH receptor
coated tubes (CT)
antigen-coated
tubes
native TSH receptor,
porcine
RIA
free triiodothyronine (FT3)
coated tubes (CT)
antibody-coated
tubes
triiodothyronine,
human
ELISA
reverse triiodothyronine (RT3)
antibody-coated
microplate wells
RIA
free thyroxine (FT4)
coated tubes (CT)
antibody-coated
tubes
thyroxine,
human
RIA
Turbo thyrotropin (TSH)
coated tubes (CT); IRMA
antibody-coated
tubes
thyrotropin,
human
RIA
calcitonin
coated tubes (CT); IRMA
antibody-coated
tubes
calcitonin,
human
IIFT
parathyroid gland
parathyroid
gland
monkey
IIFT
adrenal cortex
adrenal gland
monkey
IIFT
Endocrinology Screen (AM) EUROPattern
adrenal cortex
1 BIOCHIP per field:
adrenal gland

monkey
IIFT
antibodies against adrenal cortex
(adrenal cortex ab control)
IIFT
ovarian antigens
ovary
monkey
IIFT
Infertility Mosaic 7
ovarian antigens
Leydig cells
placental antigens
spermatozoa
uterine antigens
5 BIOCHIPs per field:
ovary
testis
placenta
smear
uterus

monkey
monkey
monkey
human
monkey
IIFT
antibodies against ovary: theca cells
(ovary ab control)
IIFT
Leydig cells
testis
monkey
IIFT
antibodies against testis: Leydig cells
(testis ab control)
IIFT
antibodies against spermatozoa
IIFT
spermatozoa
smear
human
IIFT
pituitary gland antigens
pituitary gland
(anterior + posterior lobe)
monkey
IIFT
pituitary gland antigens
pituitary gland
(anterior lobe)
monkey
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