Sexually transmitted infections

Clinical information

Sexually transmitted infections (STIs) can be caused by bacteria (e.g. Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma), viruses (e.g. HSV) or parasites (Trichomonas vaginalis), which are transmitted from person to person by vaginal, anal or oral sex. The course, symptoms and consequences of STIs can differ significantly depending on the causative pathogen. In many cases, the infection is asymptomatic, so that it remains undiscovered for a long time and is only diagnosed when it has become chronic. Infections with these pathogens often cause inflammation of the urogenital tract, which may ascend and lead to e.g. infertility.

In addition to the consequences for the patient, infections with most of the mentioned pathogens can also lead to intrauterine foetal loss, preterm birth or damage to the unborn child. Moreover, many pathogens can be transmitted to the newborn during birth, causing severe postnatal infections.

Diagnostics

The commonly used detection methods for STI are direct methods, in which the pathogen is detected by PCR or culture, and indirect methods, i.e. detection of pathogen-specific antibodies. Since detection by culturing is especially time-consuming and difficult for Chlamydia, Mycoplasma, Ureaplasma and Treponema, other detection methods, e.g. PCR-based and/or serological procedures, are generally recommended or required for these pathogens.

Selected Products

Method
Parameter
Substrate
Species/ Antigen
IIFT
antibodies against Treponema pallidum
unspecific FTA IgG positive control
IIFT
antibodies against Treponema pallidum
unspecific FTA IgM positive control
IIFT
Treponema pallidum
(FTA-ABS)
bacterial
smear
verification BIOCHIP
(2 BIOCHIPs per field)
T. pallidum
IIFT
Treponema pallidum
FTA negative control
ELISA
Treponema pallidum
antigen-coated
microplate wells
recombinant antigens
15 kDa, 17 kDa, 47 kDa,
42 kDa (TmpA)
ELISA
Treponema pallidum
incl. IgG/RF absorbent
antigen-coated
microplate wells
recombinant antigens
15 kDa, 17 kDa, 47 kDa,
42 kDa (TmpA)
ELISA
Treponema pallidum
Screen ELISA
antigen-coated
microplate wells
recombinant antigens
15 kDa, 17 kDa, 47 kDa,
42 kDa (TmpA)
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Treponema pallidum
EUROLINE
positive control serum: IgM, human, 50x concentrated
for Treponema pallidum
EUROLINE
Treponema pallidum
(TpN15, TpN17, TmpA, TpN47 separately)
EUROLINE
WESTERNBLOT
antibodies against Treponema pallidum
IgG positive control
WESTERNBLOT
antibodies against Treponema pallidum
IgM positive control
WESTERNBLOT
Treponema pallidum
Westernblot
15 kDa, 17 kDa,
45 kDa (tmpA), 47 kDa
IIFT
antibodies against Treponema pallidum
IgG positive control for FTA absorption
WESTERNBLOT
EUROLINE-WB
Treponema pallidum
plus cardiolipin
Westernblot
15 kDa, 17 kDa, 45 kDa (tmpA), 47 kDa
plus purified cardiolipin
ELISA
CSQ pair of controls
anti-Treponema pallidum (IgG)
ELISA
Treponema pallidum
antibody determination in CSF
antigen-coated
microplate wells
recombinant antigens
15 kDa, 17 kDa, 47 kDa,
42 kDa (TmpA)
IIFT
Treponema pallidum
(FTA-ABS)
bacterial
smears
verification BIOCHIP
(3 BIOCHIPs per field)
T. pallidum
T. phagedenis
IIFT
antibodies against Chlamydia trachomatis
IgA positive control
IIFT
antibodies against Chlamydia trachomatis
IgG positive control
IIFT
antibodies against Chlamydia trachomatis
IgM positive control
IIFT
Chlamydia
trachomatis
infected cells
EU 40
ELISA
Chlamydia trachomatis
antigen-coated
microplate wells
native MOMP antigen
from C. trachomatis
ELISA
Chlamydia trachomatis
antigen-coated
microplate wells
native MOMP antigen
from C. trachomatis
ELISA
Chlamydia trachomatis
incl. IgG/RF absorbent
antigen-coated
microplate wells
native MOMP antigen
from C. trachomatis
IIFT
Chlamydia spp.
negative control
WESTERNBLOT
EUROLINE-WB
Chlamydia trachomatis
Westernblot
whole antigen, SDS extract of
Chlamydia trachomatis plus MOMP antigen
IIFT
Anti-Chlamydia MIF EUROPattern
Chlamydia trachomatis
Chlamydia pneumoniae
Chlamydia psittaci
4 BIOCHIPs per field:
elementary bodies
and non-infected cells

EU 40
EU 40
EU 40
IIFT
Anti-Chlamydia MIF
Chlamydia trachomatis
Chlamydia pneumoniae
Chlamydia psittaci
4 BIOCHIPs per field:
elementary bodies
and non-infected cells

EU 40
EU 40
EU 40
IIFT
Chlamydia trachomatis
elementary bodies (MIF)
non-infected cells
(2 BIOCHIPs per field)
EU 40
EU 40
IIFT
antibodies against Mycoplasma hominis
IgG positive control
IIFT
Mycoplasma hominis/pneumoniae and
Ureaplasma urealyticum negative control
IIFT
Mycoplasma
hominis
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 38
IIFT
Mycoplasma hominis EUROPattern
Ureaplasma urealyticum EUROPattern
infected cells
infected cells
non-infected cells
(3 BIOCHIPs per field)
EU 38
EU 38
EU 38
IIFT
Mycoplasma hominis
Ureaplasma urealyticum
infected cells
infected cells
non-infected cells
(3 BIOCHIPs per field)
EU 38
EU 38
EU 38
IIFT
antibodies against Ureaplasma urealyticum
IgG positive control
IIFT
Ureaplasma
urealyticum
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 38
PCR
EURORealTime HSV-1/2
IIFT
antibodies against Herpes simplex virus 1 (HSV-1)
IgG positive control
IIFT
antibodies against Herpes simplex virus 1 (HSV-1)
IgM positive control
IIFT
Herpes simplex virus 1
(HSV-1)
infected cells
EU 38
IIFT
HSV-1/HSV-2
negative control
WESTERNBLOT
antibodies against Herpes simplex virus (HSV)
IgG positive control
IIFT
BIOCHIP Mosaic
HSV-1/HSV-2
2 BIOCHIPs per field:
infected cells

EU 38
ELISA
CSQ pair of controls
anti-HSV-1/2 Pool (IgG)
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
antibody determination in CSF
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
WESTERNBLOT
EUROLINE-WB
Herpes simplex virus 1 (HSV-1)
plus HSV-2 type-specific
glycoprotein G2
Westernblot
whole antigen, SDS extract of HSV-1
plus purified gG2
ELISA
Herpes simplex virus 1 (HSV-1)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native
glycoprotein C1
ELISA
Herpes simplex virus 1
(HSV-1)
antigen-coated
microplate wells
recombinant
glycoprotein C1
IIFT
antibodies against Herpes simplex virus 2 (HSV-2)
IgG positive control
IIFT
antibodies against Herpes simplex virus 2 (HSV-2)
IgM positive control
IIFT
Herpes simplex virus 2
(HSV-2)
infected cells
EU 38
ELISA
Herpes simplex virus 2 (HSV-2)
incl. IgG/RF absorbent
antigen-coated
microplate wells
recombinant
glycoprotein G2
ELISA
Herpes simplex virus 2
(HSV-2)
antigen-coated
microplate wells
recombinant
glycoprotein G2
EUROArray
EUROArray HPV
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