Pregnancy-relevant infections

Clinical information

The term TORCH encompasses all infectious agents that can be transferred from mother to child in the uterus, during birth or after birth via vertical infection. It includes Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), herpes simplex virus (HSV) and other pathogens such as Chlamydia trachomatis, parvovirus B19, Treponema pallidum and varicella zoster virus (VZV). Primary infections during pregnancy are especially feared, since they are associated with an increased risk of damage to the child.

Diagnostics

Analysis of antibodies against TORCH parameters is an essential part of pre-, peri- and postnatal care. The tests allow the immune status of the mother to be established and the risks to
an existing pregnancy assessed. TORCH tests are generally performed during the first trimester of pregnancy, but they can also be carried out on the newborn if an infection is suspected. The initial investigation of antibodies against TORCH pathogens is aimed at determining the immune status of the mother in order to be able to differentiate between acute primary and past infections or reactivations during the course of pregnancy. If diagnosed early, TORCH infections can in part be effectively treated, reducing the risk of birth defects or loss of the foetus.

Selected Products

Method
Parameter
Substrate
Species
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Treponema pallidum
EUROLINE
positive control serum: IgM, human, 50x concentrated
for Treponema pallidum
WESTERNBLOT
antibodies against Treponema pallidum
IgG positive control
WESTERNBLOT
antibodies against Treponema pallidum
IgM positive control
EUROLINE
Treponema pallidum
(TpN15, TpN17, TmpA, TpN47 separately)
EUROLINE
WESTERNBLOT
Treponema pallidum
Westernblot
ELISA
Treponema pallidum
antigen-coated
microplate wells
ELISA
Treponema pallidum
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Treponema pallidum
Screen ELISA
antigen-coated
microplate wells
IIFT
Treponema pallidum
(FTA-ABS)
bacterial
smear
verification BIOCHIP
(2 BIOCHIPs per field)
T. pallidum
WESTERNBLOT
EUROLINE-WB
Treponema pallidum
plus cardiolipin
Westernblot
ELISA
CSQ pair of controls
anti-Treponema pallidum (IgG)
ELISA
Treponema pallidum
antibody determination in CSF
antigen-coated
microplate wells
IIFT
Treponema pallidum
(FTA-ABS)
bacterial
smears
verification BIOCHIP
(3 BIOCHIPs per field)
T. pallidum
T. phagedenis
ELISA
Chlamydia trachomatis
antigen-coated
microplate wells
ELISA
Chlamydia trachomatis
antigen-coated
microplate wells
ELISA
Chlamydia trachomatis
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Chlamydia
trachomatis
infected cells
EU 40
IIFT
Anti-Chlamydia MIF
Chlamydia trachomatis
Chlamydia pneumoniae
Chlamydia psittaci
4 BIOCHIPs per field:
elementary bodies
and non-infected cells

EU 40
EU 40
EU 40
IIFT
Anti-Chlamydia MIF EUROPattern
Chlamydia trachomatis
Chlamydia pneumoniae
Chlamydia psittaci
4 BIOCHIPs per field:
elementary bodies
and non-infected cells

EU 40
EU 40
EU 40
IIFT
Chlamydia trachomatis
elementary bodies (MIF)
non-infected cells
(2 BIOCHIPs per field)
EU 40
EU 40
ELISA
Toxoplasma gondii
antigen-coated
microplate wells
ELISA
Toxoplasma gondii
antigen-coated
microplate wells
ELISA
Toxoplasma gondii
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Toxoplasma gondii Screen
antigen-coated
microplate wells
IIFT
Toxoplasma
gondii
protozoan
smear
Toxoplasma
gondii
ELISA
Toxoplasma gondii
avidity determination
antigen-coated
microplate wells
EUROLINE
"TO.R.C.H. 10"
(Toxoplasma gondii, Rubella virus, CMV,
HSV-1, HSV-2, Bordetella pertussis, Chlamydia trachomatis,
Parvovirus B19, Treponema pallidum, VZV separately)
EUROLINE
EUROLINE
positive control serum: IgG, human, 50x concentrated
for TO.R.C.H. Profile
EUROLINE
positive control serum: IgM, human, 50x concentrated
for TO.R.C.H. Profile
EUROLINE
"TO.R.C.H. Profile"
(Toxoplasma gondii, Rubella virus,
CMV, HSV-1, HSV-2 separately)
EUROLINE
EUROLINE
"TO.R.C.H. Profile"
(Toxoplasma gondii, ROP1, Rubella virus,
CMV, HSV-1, HSV-2 separately)
EUROLINE
ELISA
CSQ pair of controls
anti-Toxoplasma gondii (IgG)
ELISA
Toxoplasma gondii
antibody determination in CSF
antigen-coated
microplate wells
PCR
EURORealTime HSV-1/2
EUROArray
EUROArray HSV1/2 VZV
WESTERNBLOT
antibodies against Herpes simplex virus (HSV)
IgG positive control
ELISA
CSQ pair of controls
anti-HSV-1/2 Pool (IgG)
WESTERNBLOT
EUROLINE-WB
Herpes simplex virus 1 (HSV-1)
plus HSV-2 type-specific
glycoprotein G2
Westernblot
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Herpes simplex virus
(HSV-1/2 Pool)
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
BIOCHIP Mosaic
HSV-1/HSV-2
2 BIOCHIPs per field:
infected cells

EU 38
ELISA
Herpes simplex virus 1
(HSV-1)
antigen-coated
microplate wells
ELISA
Herpes simplex virus 2
(HSV-2)
antigen-coated
microplate wells
ELISA
Cytomegalovirus
(CMV)
antigen-coated
microplate wells
ELISA
Cytomegalovirus (CMV)
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Cytomegalovirus (CMV)
avidity determination
antigen-coated
microplate wells
ELISA
Cytomegalovirus (CMV) p52
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Cytomegalovirus
(CMV) gB
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-Cytomegalovirus (IgG)
ELISA
Cytomegalovirus (CMV)
antibody determination in CSF
antigen-coated
microplate wells
EUROLINE
Parvovirus B19
(VP1, VLP, VP2, NS1 separately)
EUROLINE
ELISA
Parvovirus
B19
antigen-coated
microplate wells
ELISA
Parvovirus B19
incl. IgG/RF absorbent
antigen-coated
microplate wells
WESTERNBLOT
Rubella virus
Westernblot
ELISA
Rubella virus
antigen-coated
microplate wells
IIFT
Rubella virus
infected cells
EU 13
ELISA
Rubella virus
avidity determination
antigen-coated
microplate wells
ELISA
Rubella virus glycoprotein
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-Rubella virus (IgG)
ELISA
Rubella virus
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Varicella zoster virus
(VZV)
antigen-coated
microplate wells
ELISA
Varicella zoster virus
(VZV)
antigen-coated
microplate wells
ELISA
Varicella zoster virus (VZV)
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Varicella zoster virus
(VZV)
infected cells
EU 168
ELISA
Varicella zoster virus (VZV)
avidity determination
antigen-coated
microplate wells
ELISA
Varicella zoster virus (VZV) glycoprotein
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-VZV (IgG)
ELISA
Varicella zoster virus (VZV)
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Varicella zoster virus (VZV)
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Zika virus (ZIKV)
antigen-coated
microplate wells
ELISA
Zika virus (ZIKV)
antigen-coated
microplate wells
ELISA
Zika virus (ZIKV)
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Zika virus (ZIKV)
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Zika virus (ZIKV)
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 14
IIFT
Zika virus (ZIKV) EUROPattern
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 14
PCR
EURORealTime Zika Virus
IIFT
Arbovirus Fever Mosaic 2
Zika virus (ZIKV)
Chikungunya virus (CHIKV)
Dengue virus types 1 - 4 (DENV)
6 BIOCHIPs per field:
infected cells
infected cells
infected cells

EU 14
EU 14
EU 14
IIFT
Arbovirus Fever Mosaic 2 EUROPattern
Zika virus (ZIKV)
Chikungunya virus (CHIKV)
Dengue virus types 1 - 4 (DENV)
6 BIOCHIPs per field:
infected cells
infected cells
infected cells

EU 14
EU 14
EU 14
IIFT
Arbovirus Profile 3
upper row :
Zika virus (ZIKV)
Chikungunya virus (CHIKV)
Dengue virus types 1 - 4 (DENV)
bottom row:
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)


infected cells
infected cells
infected cells

infected cells
infected cells
infected cells
infected cells


EU 14
EU 14
EU 14

EU 14
EU 14
EU 14
EU 14
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