Tick-borne infections

Clinical information

Ticks can transmit different viral, bacterial and parasitic infectious agents to a person during blood feeding. Alongside Borrelia, which causes Lyme borreliosis, the most frequent tick-borne disease in the northern hemisphere, the range of pathogens include TBE virus, Crimean-Congo fever virus, Anaplasma, Rickettsia, Babesia, Ehrlichia and Coxiella. Depending on the pathogen, tick-borne infections may lead to various clinical symptoms, with involvement of, for example, the skin, joints, muscles, inner organs and central nervous system. Disease courses range from asymptomatic or subclinical to severe and life-threatening. Since there are only vaccines to some of the tick-borne pathogens, exposition prophylaxis is the most effective protection measure. 

Diagnostics

Laboratory diagnostics of tick-borne infections are based on direct and indirect detection methods. Direct procedures include e.g. blood smears, pathogen cultures or PCR-based tests, while indirect detection is mainly based on the detection of specific antibodies against the respective pathogen in patient serum, plasma or CSF. Detection of antibodies is the most important laboratory diagnostic method in cases where it is difficult to obtain suitable sample materials for direct detection, or the amount of pathogen in the sample is too low. For antibody determination in cases of suspected tick-borne infection, EUROIMMUN offers a wide range of serological test systems, including ELISAs, ChLIAs, immunofluorescence tests (IIFT), immunoblots and EUROMicroblots, miniaturised immunoblots in microplate format.

Files

Differentiated Borrelia diagnostics

Professional article in Forum Sanitas: Diagnostic Workup and Treatment of Lyme Disease

EUROMicroblot - Efficient blot technology for high throughput

 

 Learn more about the technology and automated processing of the
 EUROMicroblots in this video.

 

Selected Products

Method
Parameter
Substrate
Species
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Borrelia
EUROLINE
positive control serum: IgM, human, 50x concentrated
for Borrelia
WESTERNBLOT
antibodies against Borrelia afzelii
IgG positive control
(Westernblot/EUROLINE-WB)
WESTERNBLOT
antibodies against Borrelia afzelii
IgM positive control
(Westernblot/EUROLINE-WB)
EUROLINE
EUROLINE Borrelia-RN-AT
(p18, p19, p20, p21, p58,
OspC (p25), p39, p83, LBb, LBa,
VlsE Bg, VlsE Bb, VlsE Ba separately)
EUROLINE
EUROLINE
EUROLINE Borrelia-RN-AT
(OspC Bg native, OspC Bb native,
OspC Ba native, p39, VlsE Bb separately)
EUROLINE
WESTERNBLOT
Borrelia afzelii
Westernblot
WESTERNBLOT
EUROLINE-WB
Borrelia
Westernblot
EUROLINE
EUROLINE Borrelia-RN-AT-adv
(OspC-adv Bsp, OspC-adv Bg, OspC-adv
Bb, OspC-adv Ba, p39, VlsE Bb separately)
EUROLINE
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgG positive control
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgM positive control
ChLIA
IDS Borrelia Burgdorferi Control Set
WESTERNBLOT
Borrelia burgdorferi
Westernblot
ELISA
Borrelia
incl. IgG/RF absorbent
antigen-coated
microplate wells
ChLIA
Borrelia
ChLIA
Borrelia
ChLIA
Control set
Borrelia
ChLIA
IDS Borrelia Burgdorferi IgG

ChLIA
IDS Borrelia Burgdorferi IgM

ELISA
Borrelia
plus VlsE
antigen-coated
microplate wells
ELISA
Lyme ELISA
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with VlsE
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with OspC advanced
antigen-coated
microplate wells
ELISA
Borrelia
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Borrelia PLUS VlsE antibody determination in CSF
antigen-coated
microplate wells
ELISA
CSQ pair of controls anti-Borrelia (IgG)
ELISA
CSQ pair of controls anti-Borrelia (IgM)
WESTERNBLOT
Borrelia burgdorferi US
EUROLINE-WB
Westernblot
WESTERNBLOT
antibodies against Borrelia garinii
IgG positive control
WESTERNBLOT
antibodies against Borrelia garinii
IgM positive control
WESTERNBLOT
Borrelia garinii
Westernblot
WESTERNBLOT
Borrelia garinii
Westernblot
IIFT
EUROPLUS
Borrelia afzelii
Borrelia burgdorferi (USA)
OspC antigen
VlsE antigen
4 BIOCHIPs per field:
bacterial smear
bacterial smear
OspC BIOCHIPs
VlsE BIOCHIPs

B. afzelii
B. burgd. (USA)
B. burgdorferi
recombinant
ELISA
Coxiella burnetii phase 1
antigen-coated
microplate wells
ELISA
Coxiella burnetii phase 2
antigen-coated
microplate wells
EUROLINE
EUROLINE Hepatitis E Virus
(separat: GT1 ORF2, GT2 ORF2,
GT3 ORF2, GT4 ORF2)
EUROLINE
ELISA
TBE virus
antigen-coated
microplate wells
ELISA
TBE virus
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
TBE virus (TBEV)
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 14
ELISA
TBE virus
avidity determination
antigen-coated
microplate wells
IIFT
Flavivirus Mosaic 1
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
4 BIOCHIPs per field:
infected cells
infected cells
infected cells
infected cells

EU 14
EU 14
EU 14
EU 14
IIFT
Flavivirus Profile 2
upper row:
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
bottom row:
Dengue virus
types 1 - 4 (DENV)


infected cells
infected cells
infected cells
infected cells

infected cells


EU 14
EU 14
EU 14
EU 14

EU 14
ELISA
TBE virus
Vienna
antigen-coated
microplate wells
ELISA
CSQ pair of controls anti-TBE virus Vienna (IgG)
ELISA
TBE virus
antibody determination in CSF
antigen-coated
microplate wells
ELISA
CSQ pair of controls anti-TBE virus (IgG)
ELISA
CSQ pair of controls anti-TBE virus (IgM)
IIFT
Crimean Congo fever virus Mosaic 2
CCHFV-GPC
CCHFV-N
3 BIOCHIPs per field:
transfected cells
transfected cells
control transfection

EU 90
EU 90
EU 90
Back to top